LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis.

Qiang FeiFeihong SongXinwei JiangHan HongXiaoyong XuZhengkang JinXiang ZhuBinghua DaiJiamei YangChengjun SuiMinhui Xu

Published in: Cancer cell international (2020)

In conclusion, our findings suggested that ST8SIA6-AS1 was a novel upregulated lncRNA in HCC and could facilitate cell proliferation and resistance to cell apoptosis via sponging miR-4656 and elevation of HDAC11, which might be a promising biomarker for patients with HCC.

Keyphrases

cell proliferation
long non coding rna
cell cycle
long noncoding rna
pi k akt
histone deacetylase
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
signaling pathway