Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14 -PGJ2 and Nogo.

Shuang ZhangMiao YuFangling GuoXiaoxiao YangYuanli ChenChuanrui MaQi LiZhuo WeiXiaoju LiHua WangHuaqing HuYujue ZhangDerun KongQing Robert MiaoWenquan HuDavid P HajjarYan ZhuJihong HanYajun Duan

Published in: British journal of pharmacology (2020)

Levels of 15d-PGJ2 and Nogo are important biomarkers for intrahepatic cholestasis. Synthetic agonists of PPARγ could be used for treatment of intrahepatic cholestasis and cholestasis-associated dyslipidemia.

Keyphrases

drug induced
insulin resistance
high fat diet induced
metabolic syndrome
combination therapy