Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters.
José Alexandre de Souza CrippaLuiz C Pereira JuniorLívia C PereiraPatrícia M ZimmermannLiberato Brum JuniorLetícia M RechiaIsabella DiasJaime Eduardo Cecílio HallakAlline Cristina de CamposFrancisco Silveira GuimarãesRegina Helena Costa QueirozAntonio Waldo ZuardiPublished in: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) (2021)
When administered as a single 150-mg dose, neither formulation of oral CBD altered responses to emotional stimuli in healthy subjects. The oil-based CBD formulation resulted in more rapid achievement of peak plasma level, with an approximate fourfold increase in oral bioavailability.