Restoring ventricular restoration: A call to re-evaluate a surgical therapy considered ineffective.
Torsten DoenstEric J VelazquezRobert E MichlerPublished in: Journal of cardiac surgery (2021)
The technique of surgical restoration of postischemically dilated left ventricles (SVR) has almost disappeared from operating theaters after the Surgical Treatment of IsChemic Heart failure (STICH) Trial demonstrated no treatment effect in patients with CAD and ejection fraction below 35%. Criticism on the trial was expressed stating that surgical expertise and patient selection (i.e., almost no aneurysm patients included) may have been inadequate to test the procedure s potential. Gaudino and colleagues now propose to conduct an analysis comparing the STICH patient population to a group of comparable SVR patients treated by a center with documented specific expertise for this technique. We here address the background of the trial and the following controversy and suggest a rationale why the suggested analysis has the potential to add valuable information to the field.
Keyphrases
- ejection fraction
- heart failure
- aortic stenosis
- phase iii
- study protocol
- clinical trial
- phase ii
- case report
- left ventricular
- end stage renal disease
- coronary artery disease
- open label
- coronary artery
- newly diagnosed
- healthcare
- minimally invasive
- human health
- atrial fibrillation
- risk assessment
- stem cells
- health information
- replacement therapy
- cardiac resynchronization therapy
- patient reported
- aortic valve
- subarachnoid hemorrhage
- placebo controlled