Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss.

Yansi XianYijie GaoYiji SuYuangang SuHaoyu LianXiaoliang FengZhijuan LiuJinmin ZhaoJiake XuQian Liu Fangming Song

Published in: Phytotherapy research : PTR (2024)

CA inhibited osteoclast activity and bone loss by targeting RANKL. CA might represent a promising candidate for treating osteoclast-related diseases, such as osteoporosis.

Keyphrases

bone loss
high glucose
postmenopausal women
diabetic rats
drug induced
protein kinase
bone mineral density
stress induced