Pediatric myelodysplastic syndrome with inflammatory manifestations: Diagnosis, genetics, treatment, and outcome.
Asaf David YanirAviva KraussJerry SteinOrna Steinberg-ShemerOded GiladSharon Noy LotanOrly DganyTatyana KrasnovYona KodmanTamar FeuersteinJacques MardoukhHila FishmanIfat GeronJoanne YacobovichHannah TamaryYehudit BirgerGalia AvrahamiShai IzraeliShlomit Barzilai BirenboimPublished in: Pediatric blood & cancer (2021)
Primary pediatric MDS with IM is driven in some cases by PTPN11 mutations, and might be on the clinical spectrum of JMML. Anti-inflammatory treatment may reverse MDS progression and improve the outcome of subsequent HSCT.