Genomic Disorders in CKD across the Lifespan.

Miguel VerbitskySarathbabu KrishnamurthyPriya KrithivasanDaniel HughesAtlas KhanMaddalena MarasàNatalie VenaPavan KhoslaJunying ZhangTze Y LimJoseph T GlessnerChunhua WengNing ShangYufeng ShenGeorge HripcsakHakon HakonarsonIuliana Ionita-LazaBrynn LevyEimear E KennyRuth J F LoosKrzysztof KirylukSimone Sanna-CherchiDavid R CrosslinSusan FurthBradley A WaradyRobert P IgoSudha K IyengarCraig S WongAfshin ParsaHarold I FeldmanAli G Gharavi

Published in: Journal of the American Society of Nephrology : JASN (2022)

Undiagnosed GDs are detected both in children and adults with CKD. Identification of GDs in these patients can enable a precise genetic diagnosis, inform prognosis, and help stratify risk in clinical studies. GDs could also provide a molecular explanation for nephropathy and comorbidities, such as poorer neurocognition for a subset of patients.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
young adults
patient reported outcomes
gene expression
dna methylation
genome wide
single molecule