Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia.
Jessica L PanmanVikram VenkatraghavanEmma Louise van der EndeRebecca M E SteketeeLize C JiskootJackie M PoosElise G P DopperLieke H H MeeterLaura Donker KaatSerge A R B RomboutsMeike W VernooijAnneke J A KievitEnrico PremiMaura CossedduElisa BonomiJaume OlivesJonathan Daniel RohrerRaquel Sánchez-ValleBarbara BorroniEsther E BronJohn Cornelis van SwietenJanne M PapmaStefan Kleinnull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Degeneration of axons and language deficits are indicated to be the earliest biomarkers in FTD-GRN, with bvFTD being more heterogeneous in disease progression than nfvPPA. Our data-driven model could help identify presymptomatic GRN mutation carriers at risk of conversion to the clinical stage.
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