Chondrogenic induction of human osteoarthritic cartilage-derived mesenchymal stem cells activates mineralization and hypertrophic and osteogenic gene expression through a mechanomiR.
Nan HuYun GaoChathuraka T JayasuriyaWenguang LiuHeng DuJing DingMeng FengQian ChenPublished in: Arthritis research & therapy (2019)
Induction of chondrogenesis can activate mineralization, hypertrophic, and osteogenic genes in OA-MSC. MiR-365 appears to be a master regulator of these differentiation processes in OA-MSC during OA pathogenesis. These findings have important implications for cartilage repair therapy using cartilage derived stem cells from OA patients.
Keyphrases
- mesenchymal stem cells
- gene expression
- knee osteoarthritis
- end stage renal disease
- bone marrow
- extracellular matrix
- cell proliferation
- ejection fraction
- endothelial cells
- newly diagnosed
- chronic kidney disease
- dna methylation
- peritoneal dialysis
- long noncoding rna
- stem cells
- transcription factor
- genome wide
- patient reported outcomes
- patient reported