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An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer.

Sandra D SchererAlessandra I RiggioFadi HarounYoko S DeRoseH Atakan EkizMaihi FujitaJennifer TonerLing ZhaoZheqi LiSteffi OesterreichAhmed A SamatarAlana L Welm
Published in: Breast cancer research : BCR (2021)
This model sets the stage for development of other clinically relevant models of human breast cancer and should allow future studies on mechanisms of endocrine resistance and tumor-immune interactions in an immune-humanized in vivo setting.
Keyphrases
  • metastatic breast cancer
  • endothelial cells
  • monoclonal antibody
  • induced pluripotent stem cells
  • childhood cancer