A Phase 1 Study of Oral Vitamin D 3 in Boys and Young Men With X-Linked Adrenoleukodystrophy.

Keith P Van HarenKristen CunananAvni AwaniMeng GuDalia PeñaLindsay C ChromikMichal PovažanNicole C RossiJordan GoodmanVandana SundaramJennifer WinterbottomGerald V RaymondTina CowanGregory M EnnsEmmanuelle WaubantLawrence SteinmanPeter B BarkerDaniel SpielmanAli Fatemi

Published in: Neurology. Genetics (2023)

This study provides Class IV evidence that fixed or weight-stratified vitamin D supplementation achieved target levels of 25-hydroxyvitamin D in boys and young men with X-ALD without brain lesions.

Keyphrases

middle aged
body mass index
open label
white matter
weight loss
resting state
physical activity
clinical trial
body weight
blood brain barrier
brain injury
placebo controlled