Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis.
Olivia C LeavyAnne F GoemansAmy D StockwellRichard J AllenBeatriz Guillen-GuioTamara Hernandez-BeeftinkAyodeji AdegunsoyeHelen L Boothnull nullPaul CullinanWilliam A FahyTasha E FingerlinHarvinder S VirkIan P HallSimon P HartMike R HillNik HiraniRichard B HubbardNaftali KaminskiShwu-Fan MaRobin J McAnultyX Rebecca ShengAnn B MillarMaria Molina-MolinaVidyia NavaratnamMargaret NeighborsHelen ParfreyGauri SainiIan SayersMary E StrekMartin D TobinMoira Kb WhyteYingze ZhangToby M MaherPhilip L MolyneauxJustin M OldhamBrian L YaspanCarlos FloresFernando MartinezCarl J ReynoldsDavid A SchwartzImre NothR Gisli JenkinsLouise V WainPublished in: medRxiv : the preprint server for health sciences (2024)
We prioritised three genetic variants whose effect on IPF risk may be modified by sex, however these require further study. We found no evidence that the predictive accuracy of common SNP-based PRSs varies significantly between males and females.