Inhibitory Metaplasticity in Juvenile Stressed Rats Restores Associative Memory in Adulthood by Regulating Epigenetic Complex G9a/GLP.

Radha RaghuramanAnoop ManakkadanGal Richter-LevinSreedharan Sajikumar

Published in: The international journal of neuropsychopharmacology (2022)

The blockade of the G9a/GLP complex was found to alleviate deficits in long-term plasticity and associative memory during the adulthood of animals exposed to juvenile stress. Our data provide insights on the long-term effects of juvenile stress that involve epigenetic mechanisms, which directly impact long-term plasticity, synaptic tagging and capture, and associative memory.

Keyphrases

working memory
dna methylation
gene expression
depressive symptoms
traumatic brain injury
stress induced
early life
machine learning
deep learning
prefrontal cortex