Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.

Silvia Alemany Artigas María Soler Judit Cabana-DomínguezDana FakhreddineNatalia Llonga Laura Vilar-Ribó Amanda Rodríguez-Urrutia Judit Palacio Ana María González-CastroBeatriz LoboCarmen Alonso-CotonerMagnus SimrénJavier SantosJosep-Antoni Ramos-Quiroga Marta Ribases

Published in: Journal of translational medicine (2023)

These findings provide evidence of the polygenic architecture of IBS, identify novel genome-wide significant variants for IBS and extend previous knowledge on the genetic overlap and relationship between gastrointestinal and mental disorders.

Keyphrases

genome wide
irritable bowel syndrome
copy number
dna methylation
healthcare
mental health
gene expression