Impacts of plasma microbial lipopolysaccharide translocation on B cell perturbations and anti-CD4 autoantibody production in people with HIV on suppressive antiretroviral therapy.
Xiaoyu FuDa ChengZhenwu LuoSonya L HeathRuth AdekunleJohn E McKinnonLisa MartinZizhang ShengEnrique EspinosaWei JiangPublished in: Cell & bioscience (2023)
. Our findings suggest that persistent LPS translocation may promote anti-CD4 autoreactive B cell activation and antiCD4IgG production in PWH on ART, which may contribute to gradual CD4 + T cell depletion. This study suggests that reversing a compromised mucosal barrier could improve ART outcomes in PWH who fail to experience complete immune restoration.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv infected patients
- hiv aids
- inflammatory response
- microbial community
- toll like receptor
- nk cells
- adipose tissue
- anti inflammatory
- lps induced
- type diabetes
- metabolic syndrome
- ulcerative colitis
- south africa
- skeletal muscle
- glycemic control