Thrombolysis for ischaemic stroke despite direct oral anticoagulation.

Jan Christoph Purrucker Thomas Raphael MeinelDuncan WilsonYing XianTeddy Y Wu David Julian Seiffge

Published in: Stroke and vascular neurology (2024)

Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical consequences are discussed.

Keyphrases

direct oral anticoagulants
venous thromboembolism
pulmonary embolism
atrial fibrillation
acute ischemic stroke
weight gain
electronic health record
high dose
big data
clinical practice
low dose
body mass index
machine learning
artificial intelligence
weight loss
deep learning