Total Synthesis of (-)-FD-838 and (-)-Cephalimysin A.

Published in: Organic letters (2019)

We completed a nine-step total synthesis of (-)-FD-838 and (-)-cephalimysin A. Our synthesis features a biogenetically guided assembly of the highly oxidized spirocyclic core by Snider-type tandem epoxidations of the chiral substrate derived from an amino acid derivative. Our synthetic approach provides a general and versatile solution to access spirocyclic PKS-NRPS-based secondary fungal metabolites.

Keyphrases

amino acid
ms ms
low density lipoprotein
capillary electrophoresis
ionic liquid
mass spectrometry
cell wall
solid state
structural basis