Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients.

Su Yin LimJenny H LeeSarah J WelshSeong Beom AhnEdmond BreenAlamgir KhanMatteo S CarlinoAlexander M MenziesRichard F KeffordRichard A ScolyerGeorgina V LongHelen Rizos

Published in: Biomarker research (2017)

Our study highlights significant limitations imposed by inconsistent sensitivity and specificity due to differences in the detection antibodies or aptamers of these widespread biomarker discovery approaches. Our findings emphasize the need to improve these technologies for the accurate identification of biomarkers.

Keyphrases

high throughput
end stage renal disease
newly diagnosed
small molecule
ejection fraction
chronic kidney disease
label free
high resolution
single cell
bioinformatics analysis