Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury.
Hiran A PragDunja AksentijevicAndreas DannhornAbigail V GilesJohn F MulveyOlga SauchankaLuping DuGeorgina R BatesJohannes ReinholdDuvaraka Kula-AlwarZhelong XuLuc PellerinRichard J A GoodwinMichael P MurphyThomas KriegPublished in: Circulation research (2022)
Cardioprotection by malonate is dependent on its entry into cardiomyocytes. This is facilitated by the local decrease in pH that occurs during ischemia, leading to its selective uptake upon reperfusion into the at-risk tissue, via MCT1. Thus, malonate's preferential uptake in reperfused tissue means it is an at-risk tissue-selective drug that protects against cardiac ischemia/reperfusion injury.