Plasma pharmacokinetics and pharmacodynamic effects of the 2-benzylbenzimidazole synthetic opioid, isotonitazene, in male rats.

Sara E WaltonAlex J KrotulskiGrant C GlatfelterDonna WaltherBarry K LoganMichael H Baumann

Published in: Psychopharmacology (2022)

In summary, isotonitazene is a potent MOR agonist whose pharmacodynamic effects are related to circulating concentrations of the parent drug. The high potency of isotonitazene portends substantial risk to users who are exposed to the drug.

Keyphrases

chronic pain
pain management
drug induced
adverse drug
anti inflammatory