METH exposure alters sperm DNA methylation in F0 mice and mPFC transcriptome in male F1 mice.

Zhaosu LiDekang LiuGuanxiong WangYanyan ZhengLiying ChenZhen ChengZijing ZhangQinglong CaiFeifei GeYu FanXiaowei Guan

Published in: Psychopharmacology (2023)

Our findings put new insights into paternal METH exposure-altered profiles of F0 sperm DNA methylation and male F1 mPFC transcriptomics. Several genes, such as Sort1 and Shank2, might be used as potential molecules for further research on the transgenerational vulnerability to drug addiction in offspring by paternal drug exposure.

Keyphrases

dna methylation
genome wide
gene expression
climate change
type diabetes
high fat diet
metabolic syndrome
wild type
skeletal muscle
drug induced
human health