Thanksgiving to Yeast, the HMGB Proteins History from Yeast to Cancer.
Mónica Lamas-MaceirasÁngel Vizoso-VázquezAida Barreiro-AlonsoMaría Cámara-QuílezMaría Esperanza CerdánPublished in: Microorganisms (2023)
Yeasts have been a part of human life since ancient times in the fermentation of many natural products used for food. In addition, in the 20th century, they became powerful tools to elucidate the functions of eukaryotic cells as soon as the techniques of molecular biology developed. Our molecular understandings of metabolism, cellular transport, DNA repair, gene expression and regulation, and the cell division cycle have all been obtained through biochemistry and genetic analysis using different yeasts. In this review, we summarize the role that yeasts have had in biological discoveries, the use of yeasts as biological tools, as well as past and on-going research projects on HMGB proteins along the way from yeast to cancer.
Keyphrases
- saccharomyces cerevisiae
- dna repair
- gene expression
- papillary thyroid
- dna damage
- squamous cell
- endothelial cells
- induced apoptosis
- lymph node metastasis
- single cell
- dna damage response
- stem cells
- childhood cancer
- signaling pathway
- genome wide
- human health
- risk assessment
- induced pluripotent stem cells
- endoplasmic reticulum stress
- mesenchymal stem cells
- copy number