Training programs in preclinical studies. The example of pulmonary hypertension. Systematic review and meta-analysis.

Despite a wide spectrum of study protocols to measure exercise endurance in animals with PH, there is a significant correlation between worsening of exercise-related parameters and PH development, manifested by alterations in haemodynamic and remodeling parameters. Familiarization with exercise, training program schedule, method used for PH induction, or detailed training parameters such as slope, exercise intensity or individualization, can influence the final outcome. This in turn can impact on the diversity and reproducibility of results being obtained in particular experimental studies.