Germline mutations of Holliday junction resolvase genes in multiple primary malignancies involving lung cancer lead to PARP inhibitor sensitization.

Haoran Wang Yuping Chen Xinshu Wang Binhao Huang Juntao Xie Hui Yin Jie Yang Jinhuan Wu Jian Yuan Jie Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

This is the first study to map the profile of germline mutations in patients with MPMs involving lung cancer. This study may shed light on early prevention and novel targeted therapies for MPMs involving lung cancer patients with HJR mutations.

Keyphrases

dna repair
dna damage
gene expression
genome wide