A targeted solution for estimating the cell-type composition of bulk samples.

Edwin J C G van den OordLin Y XieCharles J TranMin ZhaoKarolina A Aberg

Published in: BMC bioinformatics (2021)

This cost-effective approach for estimating cell-type proportions in bulk samples allows for enhanced targeted analysis, which in turn will minimize the risk of reporting false-positive findings and allowing for detection of cell-type specific associations. The approach is applicable across platforms and can be extended to assess cell-type proportions for various tissues.

Keyphrases

cancer therapy
gene expression
sensitive detection
loop mediated isothermal amplification
adverse drug
fluorescent probe
drug delivery
real time pcr