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Mercaptopurine-induced Sweet's syndrome.

Natalie ComminsDeloshaan SubhaharanAndrew DettrickDesmond Patrick
Published in: BMJ case reports (2024)
Sweet's syndrome is an acute febrile neutrophilic dermatosis. Drug-induced Sweet's syndrome typically occurs soon after drug administration, with rapid resolution of symptoms with cessation of the offending agent. We report a man in his early 40s who presented with fever and widespread erythematous rash on a background of recently diagnosed mild stricturing ileal Crohn's disease. He was commenced on 6-mercaptopurine 12 days before presentation. Skin biopsy demonstrated diffuse infiltration of neutrophils in the upper dermis, dermal oedema, eosinophils and fibrin deposition. Symptoms rapidly improved with cessation of 6-mercaptopurine without requiring systemic corticosteroids.
Keyphrases
  • drug induced
  • liver injury
  • case report
  • drug administration
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  • physical activity
  • intensive care unit
  • ultrasound guided
  • single molecule
  • wound healing
  • soft tissue
  • stress induced
  • sensitive detection