Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy.

Bi LiuYunzhu ShenHuafang HuangKimiko Della CroceMin WuYingjuan FanYang LiuJianhua XuGuang Yao

Published in: Cell communication and signaling : CCS (2020)

C212 effectively eliminates both growing and quiescent leukemia cells by inhibiting Hsp90. The property of C212 to kill quiescent leukemia cells in deep dormancy avoids the risk associated with awaking therapy-resistant subpopulation of quiescent leukemia cells during treatments, which may lead to the development of novel therapies against leukemia relapse. Video abstract.

Keyphrases

induced apoptosis
cell cycle arrest
acute myeloid leukemia
bone marrow
signaling pathway
oxidative stress
stem cells
mesenchymal stem cells
heat shock protein
heat stress
heat shock
neural stem cells