Placental Malaria Induces a Unique Placental Methylation Profile Associated with Fetal Growth Restriction.

Nida OzarslanCorina MongJohn AtegekaLin LiSirirak BuarpungJoshua F RobinsonJimmy KizzaAbel KakuruMoses R Kamya Grant DorseyPhilip J RosenthalStephanie L Gaw

Published in: bioRxiv : the preprint server for biology (2024)

Placentas from pregnancies with PM-associated FGR showed distinct methylation profiles as compared to non-malarial FGR, suggesting novel epigenetic reprogramming in response to malaria. There may be distinct long-term health outcomes in FGR pregnancies also complicated by PM.

Keyphrases

plasmodium falciparum
dna methylation
particulate matter
air pollution
preterm birth
genome wide
polycyclic aromatic hydrocarbons
gestational age
heavy metals
gene expression
pregnancy outcomes
water soluble
pregnant women