Influences of preoperative metformin on immunological factors in early breast cancer.

Takahiro TsukiokiTadahiko ShienTakehiro TanakaYoko SuzukiYukiko KajiharaMinami HatonoKengo KawadaMariko KochiTakayuki IwamotoHirokuni IkedaNaruto TairaHiroyoshi DoiharaShinichi Toyooka

Published in: Cancer chemotherapy and pharmacology (2020)

Preoperative metformin tends to increase TILs, as well as the numbers of CD4 and CD8 positive lymphocytes, and IFNγ levels. Metformin might improve immune function and have a possibility of chemo-sensitivity and thereby increase the effectiveness of immunotherapy, based on the results of this preliminary study.

Keyphrases

early breast cancer
patients undergoing
systematic review
photodynamic therapy
nk cells
immune response
peripheral blood
cancer therapy
squamous cell carcinoma
combination therapy
locally advanced