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CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T H 1 and T H 9 cells.

Isis Benoit-LizonElise JacquinThaiz Rivera VargasCorentin RichardAurélie RousseyLudivine Dal ZuffoTiffany MartinAndréa MelisDaria VinokurovaSayyed Hamed ShahoeiAlvaro Baeza GarciaCassandre PignolStéphane GiorgiuttiRaphaël CarapitoRomain BoidotFrédérique VégranRichard A FlavellBernhard RyffelEric R NelsonPauline Soulas-SprauelToby LawrenceLionel Apetoh
Published in: Journal for immunotherapy of cancer (2022)
Our results reveal the STING signaling pathway as a therapeutic target to boost CD4 T-cell effector functions and antitumor immunity.
Keyphrases
  • induced apoptosis
  • signaling pathway
  • regulatory t cells
  • dendritic cells
  • cell cycle arrest
  • pi k akt
  • type iii
  • endoplasmic reticulum stress
  • oxidative stress
  • genome wide
  • single cell
  • gene expression
  • immune response