Neural stem cell-derived exosomes regulate cell proliferation, migration, and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia.
Xiaojun DengXiaoyi HuShang WangHui ZhaoYaqin WeiJiaqi FuWen-Hui WuJin-Ming LiuCaicai ZhangLili WangPing YuanPublished in: Animal models and experimental medicine (2024)
NSC-derived EXOs can promote BMEC proliferation and migration and reduce cell death via the miR-9/Hes1 axis under hypoxic conditions. Therefore, EXO therapeutic strategies could be considered for hypoxia-induced vascular injury.
Keyphrases
- cell proliferation
- cell death
- stem cells
- endothelial cells
- long non coding rna
- cell cycle
- cell cycle arrest
- long noncoding rna
- pi k akt
- mesenchymal stem cells
- white matter
- resting state
- vascular endothelial growth factor
- signaling pathway
- brain injury
- multiple sclerosis
- functional connectivity
- blood brain barrier
- cerebral ischemia
- subarachnoid hemorrhage