Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice During Acute Base-loading.

Peder BergTobias JensenJesper Frank AndersenSamuel Levi Svendsen Ida Maria ModvigTobias WangSebastian Frische Billy Kwok Chong Chow Hans Malte Jens Juul Holst Mads Vaarby Sorensen Jens Leipziger

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our results suggest that loss of SCTR impairs the appropriate increase of renal base excretion during acute base loading, and that SCTR is necessary for acute correction of metabolic alkalosis. Additionally, our findings suggest that blood alkalinity increases secretin release from the small intestine, and that secretin action is critical for bicarbonate homeostasis.

Keyphrases

liver failure
respiratory failure
drug induced
aortic dissection
intensive care unit
mechanical ventilation
binding protein