A photo-responsive self-healing hydrogel loaded with immunoadjuvants and MoS 2 nanosheets for combating post-resection breast cancer recurrence.
Siyu WangZhuoping QianHuaxin XiaoGuangwen YangZiyi ZhuYubin GuJunjie SongXin ZhangXinxuan HuangLixing WengYu GaoWen Jing YangLian-Hui WangPublished in: Nanoscale (2024)
Tumor recurrence after surgical resection remains a significant challenge in breast cancer treatment. Immune checkpoint blockade therapy, as a promising alternative therapy, faces limitations in combating tumor recurrence due to the low immune response rate. In this study, we developed an implantable photo-responsive self-healing hydrogel loaded with MoS 2 nanosheets and the immunoadjuvant R837 (PVA-MoS 2 -R837, PMR hydrogel) for in situ generation of tumor-associated antigens at the post-surgical site of the primary tumor, enabling sustained and effective activation of the immune response. This PMR hydrogel exhibited potential for near-infrared (NIR) light response, tissue adhesion, self-healing, and sustained adjuvant release. When implanted at the site after tumor resection, NIR irradiation triggered a photothermal effect, resulting in the ablation of residual cancer cells. The in situ -generated tumor-associated antigens promoted dendritic cell (DC) maturation. In a mouse model, PMR hydrogel-mediated photothermal therapy combined with immune checkpoint blockade effectively inhibited the recurrence of resected tumors, providing new insights for combating post-resection breast cancer recurrence.
Keyphrases
- drug delivery
- dendritic cells
- immune response
- cancer therapy
- wound healing
- quantum dots
- drug release
- hyaluronic acid
- reduced graphene oxide
- mouse model
- photodynamic therapy
- tissue engineering
- free survival
- highly efficient
- visible light
- early stage
- radiation therapy
- transition metal
- escherichia coli
- fluorescence imaging
- regulatory t cells
- gold nanoparticles
- mesenchymal stem cells
- fluorescent probe
- climate change
- young adults
- electron transfer