Free-Water Imaging of the Substantia Nigra in GBA Pathogenic Variant Carriers.

Dongling ZhangYuting ShiJunye Yao Liche ZhouHongjiang WeiLiche ZhouQiqi TongLingyan MaHongjian HeTao Wu

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

We demonstrate that free water values are elevated in the substantia nigra and predict the development of non-motor symptoms in GBA-NMC and GBA-PD. Our findings demonstrate that a significant nigral impairment already exists in GBA-NMC, and nigral injury may be more severe in GBA-PD than in iPD. These results support that free-water imaging can as a potential early marker of substantia nigra damage. © 2023 International Parkinson and Movement Disorder Society.

Keyphrases

high resolution
oxidative stress
early onset
depressive symptoms
physical activity
risk assessment
photodynamic therapy