Galphimia glauca and Natural Galphimines Block Schizophrenia-Like Symptoms Induced with Apomorphine and MK-801 in Mice.

Mayra Alejandra Santillán-UrquizaMaribel Herrera-Ruiz Alejandro Zamilpa Jesús Enrique Jimenez-FerrerRubén Román-RamosElian Yuritzi Alegría-HerreraJaime Tortoriello

Published in: Evidence-based complementary and alternative medicine : eCAM (2019)

G. glauca and their derivatives products (GRF and galphimines) were able to interact with the dopaminergic and glutamatergic drugs and to block different behaviors associated with some of the positive, negative, and cognitive symptoms of induced schizophrenia in mice. It is necessary to continue with this research, in order to identify their mechanism of action.

Keyphrases

bipolar disorder
high glucose
diabetic rats
drug induced
high fat diet induced
oxidative stress
sleep quality
type diabetes
physical activity
adipose tissue
depressive symptoms
wild type