Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.
Moritz von ScheidtSabine BauerAngela MaKe HaoThorsten KesslerBaiba VilneYing WangChani J HodonskySaikat K B GhoshMichal MokryHua GaoKenji KawaiAtsushi SakamotoJuliane KaiserDario BongiovanniJulia FleigLilith OldenbuettelZhifen ChenAldo MoggioHendrik B SagerJudith S HeckerFlorian BassermannLars MaegdefesselClint L MillerWolfgang KoenigAndreas M ZeiherStefanie DimmelerMatthias GrawChristian BraunArno RuusaleppNicholas J LeeperJason C KovacicJohan L M BjörkegrenHeribert SchunkertPublished in: medRxiv : the preprint server for health sciences (2023)
Deep-DNA-sequencing reveals a high prevalence of CHIP mutations in whole blood of CAD patients. CHIP-affected leukocytes invade plaques in human coronary arteries. RNAseq data obtained from macrophages of CHIP-affected patients suggest that pro-atherosclerotic signaling differs depending on the underlying mutations. Further studies are necessary to understand whether specific pathways affected by CHIP mutations may be targeted for personalized treatment.