Optimized workflow for unknown screening using gas chromatography high-resolution mass spectrometry expands identification of contaminants in silicone personal passive samplers.
Steven C TravisKatarzyna KordasDiana S AgaPublished in: Rapid communications in mass spectrometry : RCM (2021)
This study provides three important findings: (1) a clear evidence of the importance of sample cleanup in addressing complex sample matrices for unknown analysis, (2) a valuable workflow for the identification of unknown contaminants in silicone wristband samplers using electron ionization HRMS data, and (3) a novel application of GC/Orbitrap™ MS for the unknown analysis of organic contaminants that can be used in exposomics studies.
Keyphrases
- gas chromatography
- high resolution mass spectrometry
- mass spectrometry
- tandem mass spectrometry
- ultra high performance liquid chromatography
- liquid chromatography
- solid phase extraction
- electronic health record
- gas chromatography mass spectrometry
- drinking water
- multiple sclerosis
- bioinformatics analysis
- simultaneous determination
- big data
- machine learning
- solar cells
- case control