Negative Predictive Value of Circulating Tumor Tissue Modified Viral (TTMV)-HPV DNA for HPV-driven Oropharyngeal Cancer Surveillance.

Glenn J Hanna Scott A Roof James Jabalee Eleni M Rettig Rocco M Ferrandino Sida Chen Marshall R Posner Krzysztof J Misiukiewicz Eric M Genden Raymond L Chai John Sims Elaine Thrash Scott J Stern Noah S Kalman Sreenija Yarlagadda Adam Raben Lydia Clements Abie H Mendelsohn John M Kaczmar Yadav Pandey Mihir K Bhayani Piyush B Gupta Charlotte Kuperwasser Catherine Del Vecchio Fitz Barry M Berger

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

TTMV-HPV DNA surveillance testing yields few false negative results and few missed recurrences. These data could inform decisions on when to pursue re-imaging following first disease restaging and could inform future surveillance practice. Additional study of how pre-treatment TTMV-HPV DNA status impacts sensitivity for recurrence is needed.

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