Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase (FIH) regulation in chronic kidney disease.
Anna FaivreRomain DissardWilly KuoThomas VerissimoDavid LegouisGrégoire ArnouxCarolyn HeckenmeyerMarylise FernandezMatthieu TihyRenuga D RajaramVasiliki DelitsikouNgoc An LeBernhard SpinglerBert MuellerGeorg ShulzMaja LindenmeyerClemens CohenJoseph M RutkowskiSolange MollCarsten C ScholzVartan KurtcuogluSophie de SeigneuxPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
The causative role of hypoxia and HIF activation in CKD progression is questioned. A pharmacological approach of FIH downregulation seem promising in proteinuric kidney disease.