SGK1 Inhibits Autophagy in Murine Muscle Tissue.

Theresia ZulegerJulia HeinzelbeckerZsuzsanna TakacsCatherine HunterJakob VoelklFlorian Lang Tassula Proikas-Cezanne

Published in: Oxidative medicine and cellular longevity (2018)

Combined, our data strongly support the idea that SGK1 inhibits the process of autophagy. Mechanistically, our data suggest that SGK1 should act upstream of ULK1 in regulating autophagy, and we hypothesize that SGK1 contributes to the regulation of ULK1 gene expression.

Keyphrases

cell death
gene expression
endoplasmic reticulum stress
signaling pathway
oxidative stress
electronic health record
big data
skeletal muscle
machine learning
data analysis
artificial intelligence