Effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice.
Jiangshan YouMengyao ZhaoShumin ChenLihua JiangShuhong GaoHao YinLiming ZhaoPublished in: Bioresources and bioprocessing (2022)
Chitooligosaccharides (COS) are found naturally in the ocean and present a variety of physiological activities, of which hypoglycemic action has attracted considerable research attention. This study aimed to assess the therapeutic effect of COS on mice suffering from type 2 diabetes mellitus (T2DM). COS effectively reduced blood glucose and blood lipid levels and improved glucose tolerance. Furthermore, COS revealed strong inhibitory activity against α-glucosidase, reducing postprandial blood glucose levels. Molecular docking data showed that COS might interact with surrounding amino acids to form a complex and decrease α-glucosidase activity. Additionally, COS enhanced insulin signal transduction and glycogen synthesis while restricting gluconeogenesis in the liver and muscles, reducing insulin resistance (IR) as a result. Moreover, COS effectively protected and restored islet cell function to increase insulin secretion. These results indicated that COS exhibited a significant hypoglycemic effect with multi-target participation. Therefore, COS may serve as a new preventive or therapeutic drug for diabetes to alleviate metabolic syndrome.
Keyphrases
- blood glucose
- glycemic control
- molecular docking
- type diabetes
- insulin resistance
- metabolic syndrome
- high fat diet induced
- cardiovascular disease
- blood pressure
- molecular dynamics simulations
- weight loss
- emergency department
- amino acid
- working memory
- machine learning
- cardiovascular risk factors
- artificial intelligence
- uric acid