Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease.
Chen-Pei LinIrene FrigerioJohn G J M BolMaud M A BouwmanAlex J WesselingMartin J DahlAnnemieke J M RozemullerYsbrand D van der WerfPetra J W PouwelsWilma D J van de BergLaura E JonkmanPublished in: Translational neurodegeneration (2024)
In AD and PD, the diffusion MRI-detected alterations within the LC and its tracts to the DLPFC and the M1 were associated with local noradrenergic neuronal loss within the LC, rather than noradrenergic changes in the cortex.