Redox modifications of cysteine residues regulate the cytokine activity of HMGB1.

Huan YangPeter LundbäckLars OttossonHelena Erlandsson-HarrisEmilie VenereauMarco E BianchiYousef Al-AbedUlf AnderssonKevin J Tracey

Published in: Molecular medicine (Cambridge, Mass.) (2021)

These results reveal critical post-translational redox mechanisms that control the proinflammatory activity of HMGB1 and its inactivation during inflammation.

Keyphrases

oxidative stress
gene expression
living cells