HMGA1 Regulates the Stem Cell-Like Properties of Circulating Tumor Cells from GIST Patients via Wnt/β-Catenin Pathway.
Ming ChenKangjing XuBowen LiNuofan WangQiang ZhangLiang ChenDiancai ZhangLi YangZekuan XuHao XuPublished in: OncoTargets and therapy (2020)
Our findings indicate the significant role of HMGA1 in SC-like properties, IM resistance and eventually hepatic metastasis formation of CTCs. Targeting HMGA1 in CTCs may be a therapeutic strategy for GIST patients with hepatic metastasis.