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Improvement of the therapeutic capacity of insulin-producing cells trans-differentiated from human liver cells using engineered cell sheet.

Yu Na LeeHye-Jin YiEun Hye SeoJooyun OhSong LeeSarah FerberTeruo OkanoIn Kyong ShimSong Cheol Kim
Published in: Stem cell research & therapy (2021)
In conclusion, cell sheet formation enhanced the differentiation function and maturation of IPCs in vitro. Additionally, parameters for clinical application such as distribution, therapeutic efficacy, and toxicity were favorable. The cell sheet technique may be used with IPCs derived from various cell sources in clinical applications.
Keyphrases
  • single cell
  • cell therapy
  • type diabetes
  • stem cells
  • oxidative stress
  • cell cycle arrest
  • metabolic syndrome
  • adipose tissue
  • mesenchymal stem cells