Molecular features of luminal breast cancer defined through spatial and single-cell transcriptomics.

Ryohei YoshitakeHitomi MoriDesiree HaXiwei WuJinhui WangXiaoqiang WangKohei SaekiGregory ChangHyun Jeong ShimYin ChanShiuan Chen

Published in: Clinical and translational medicine (2024)

Our study identified the gene signature in our 'proliferative' compartment as an important determinant of luminal cancer subtypes. This 'proliferative' cell population is a causative feature of luminal B breast cancer, contributing toward its aggressive behaviours.

Keyphrases

single cell
rna seq
high throughput
papillary thyroid
machine learning
genome wide
copy number
deep learning
cell therapy
squamous cell carcinoma
stem cells
dna methylation
single molecule
neural network