Assessing the utility of routine viral surveillance performed in children undergoing autologous stem cell transplantation at a single centre.
David Anthony FoleyJessica Win See WongAoife KeaneShanti RamachandranChristopher C BlythDaniel K YeohPublished in: Pediatric blood & cancer (2022)
We assessed the utility of routine viral surveillance for cytomegalovirus, Epstein-Barr virus and human adenovirus in children <16 years, undergoing autologous stem cell transplantation (ASCT) at a single centre over a 10-year period. A total of 85 ASCT were performed in 65 patients. Routine viral surveillance resulted in a high number of tests performed (median 20 tests per ASCT), without any clinically significant viral detections. These data support the limited clinical utility of routine viral surveillance in children undergoing ASCT. Adopting a clinically driven approach for viral testing is likely to be both cost-effective and safe.
Keyphrases
- stem cell transplantation
- sars cov
- epstein barr virus
- high dose
- public health
- clinical practice
- young adults
- end stage renal disease
- bone marrow
- diffuse large b cell lymphoma
- chronic kidney disease
- endothelial cells
- newly diagnosed
- ejection fraction
- electronic health record
- peritoneal dialysis
- patient reported outcomes