Lifestyle-dependent microglial plasticity: training the brain guardians.
Marcus Augusto-OliveiraAlexei VerkhratskyPublished in: Biology direct (2021)
Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performance and cognitive longevity. In particular, physical exercise, exposure to enriched environment and dieting act through complex modifications of microglial cells, which change their phenotype and modulate their functional activity thus translating lifestyle events into remodelling of brain homoeostasis and reshaping neural networks ultimately enhancing neuroprotection and cognitive longevity.
Keyphrases
- physical activity
- metabolic syndrome
- resting state
- weight loss
- cardiovascular disease
- white matter
- neural network
- cerebral ischemia
- inflammatory response
- induced apoptosis
- functional connectivity
- healthcare
- lipopolysaccharide induced
- lps induced
- body mass index
- brain injury
- quality improvement
- multiple sclerosis
- oxidative stress
- drosophila melanogaster
- type diabetes
- subarachnoid hemorrhage
- depressive symptoms
- cell death