Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study.

Symen LigthartNatalie R HasbaniFariba AhmadizarThijs T W van HerptMaarten J G LeeningAndré G UitterlindenEric J G SijbrandsAlanna C MorrisonEric BoerwinkleJames S PankowElizabeth SelvinM Arfan IkramMaryam KavousiPaul S de VriesAbbas Dehghan

Published in: Diabetic medicine : a journal of the British Diabetic Association (2021)

Genetic variants for type 2 diabetes have value in estimating the lifetime risk of type 2 diabetes. Normal weight mitigates partly the deleterious effect of high genetic risk.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
cardiovascular disease
genome wide
body mass index
physical activity
radiation therapy
adipose tissue
skeletal muscle
dna methylation
high fat diet induced