A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis.
Yan Hua LeeYu-Shuen TsaiChe-Chang ChangChun-Chen HoHsiu-Ming ShihHui-Mei ChenHsing-Lin LaiChia-Wei LeeYi-Chung LeeYi-Chu LiaoUeng-Cheng YangTzu-Hao ChengYijuang ChernBing-Wen SoongPublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
, is associated with late AO in polyQ disease patients and milder disease severity in HD mice. Our study highlights the possibility of targeting PIAS1 or pathways governing protein homeostasis as a disease-modifying approach for treating patients with HD. © 2021 International Parkinson and Movement Disorder Society.